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    block this user Anthony Finkelstein

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    Computer Science, UCL, London

    Ontology-based Queries over Cancer Data

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    The ever-increasing amount of data in biomedical research, and in cancer research in particular, needs to be managed to support efficient data access, exchange and integration. Existing software infrastructures, such caGrid, support access to distributed information annotated with a domain ontology. However, caGrid's current querying functionality depends on the structure of individual data resources without exploiting the semantic annotations. In this paper, we present the design and development of an ontology-based querying functionality that consists of: the generation of OWL2 ontologies from the underlying data resources metadata and a query rewriting and translation process based on reasoning, which converts a query at the domain ontology level into queries at the software infrastructure level. We present a detailed analysis of our approach as well as an extensive performance evaluation. While the implementation and evaluation was performed for the caGrid infrastructure, the approach could be applicable to other model and metadata-driven environments for data sharing.

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    Description

    Title : Ontology-based Queries over Cancer Data
    Author(s) : Alejandra Gonzalez-Beltran, Ben Tagger, Anthony Finkelstein
    Abstract : The ever-increasing amount of data in biomedical research, and in cancer research in particular, needs to be managed to support efficient data access, exchange and integration. Existing software infrastructures, such caGrid, support access to distributed information annotated with a domain ontology. However, caGrid's current querying functionality depends on the structure of individual data resources without exploiting the semantic annotations. In this paper, we present the design and development of an ontology-based querying functionality that consists of: the generation of OWL2 ontologies from the underlying data resources metadata and a query rewriting and translation process based on reasoning, which converts a query at the domain ontology level into queries at the software infrastructure level. We present a detailed analysis of our approach as well as an extensive performance evaluation. While the implementation and evaluation was performed for the caGrid infrastructure, the approach could be applicable to other model and metadata-driven environments for data sharing.
    Keywords : cagrid, ontology, owl2, query, sequence pattern, uml

    Subject : unspecified
    Area : Other
    Language : English
    Year : 2010

    Affiliations Computer Science, UCL, London
    Journal : Language
    Pages : 1-16
    Url : http://arxiv.org/abs/1012.5506

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    Anthony's Peer Evaluation activity

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