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    block this user Werner Muller

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    Faculty of Life Science, University of Manchester, Manchester

    Intestinal tolerance requires gut homing and expansion of FoxP3+ regulatory T cells in the lamina propria.

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    Tolerance to food antigen manifests in the absence and/or suppression of antigen-specific immune responses locally in the gut but also systemically, a phenomenon known as oral tolerance. Oral tolerance is thought to originate in the gut-draining lymph nodes, which support the generation of FoxP3(+) regulatory T (Treg) cells. Here we use several mouse models to show that Treg cells, after their generation in lymph nodes, need to home to the gut to undergo local expansion to install oral tolerance. Proliferation of Treg cells in the intestine and production of interleukin-10 by gut-resident macrophages was blunted in mice deficient in the chemokine (C-X3-C motif) receptor 1 (CX3CR1). We propose a model of stepwise oral tolerance induction comprising the generation of Treg cells in the gut-draining lymph nodes, followed by migration into the gut and subsequent expansion of Treg cells driven by intestinal macrophages.

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    Description

    Title : Intestinal tolerance requires gut homing and expansion of FoxP3+ regulatory T cells in the lamina propria.
    Author(s) : Usriansyah Hadis, Benjamin Wahl, Olga Schulz, Matthias Hardtke-Wolenski, Angela Schippers, Norbert Wagner, Werner Müller, Tim Sparwasser, Reinhold Förster, Oliver Pabst
    Abstract : Tolerance to food antigen manifests in the absence and/or suppression of antigen-specific immune responses locally in the gut but also systemically, a phenomenon known as oral tolerance. Oral tolerance is thought to originate in the gut-draining lymph nodes, which support the generation of FoxP3(+) regulatory T (Treg) cells. Here we use several mouse models to show that Treg cells, after their generation in lymph nodes, need to home to the gut to undergo local expansion to install oral tolerance. Proliferation of Treg cells in the intestine and production of interleukin-10 by gut-resident macrophages was blunted in mice deficient in the chemokine (C-X3-C motif) receptor 1 (CX3CR1). We propose a model of stepwise oral tolerance induction comprising the generation of Treg cells in the gut-draining lymph nodes, followed by migration into the gut and subsequent expansion of Treg cells driven by intestinal macrophages.
    Keywords : adoptive transfer, animals, cell division, chemotaxis, leukocyte, diarrhea, diarrhea etiology, diarrhea immunology, food hypersensitivity, food hypersensitivity complications, food hypersensitivity immunology, forkhead transcription factors, forkhead tran

    Subject : unspecified
    Area : Other
    Language : English
    Year : 2011

    Affiliations Faculty of Life Science, University of Manchester, Manchester
    Journal : Immunity
    Volume : 34
    Issue : 2
    Publisher : Springer-Verlag
    Pages : 237-246
    Url : http://www.ncbi.nlm.nih.gov/pubmed/21333554

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