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    Ronin Institute, Montclair, NJ

    What good is genomic imprinting: the function of parent-specific gene expression.

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    Parent-specific gene expression (genomic imprinting) is an evolutionary puzzle because it forgoes an important advantage of diploidy-protection against the effects of deleterious recessive mutations. Three hypotheses claim to have found a countervailing selective advantage of parent-specific expression. Imprinting is proposed to have evolved because it enhances evolvability in a changing environment, protects females against the ravages of invasive trophoblast, or because natural selection acts differently on genes of maternal and paternal origin in interactions among kin. The last hypothesis has received the most extensive theoretical development and seems the best supported by the properties of known imprinted genes. However, the hypothesis is yet to provide a compelling explanation for many examples of imprinting.

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    Description

    Title : What good is genomic imprinting: the function of parent-specific gene expression.
    Author(s) : Jon F Wilkins, David Haig
    Abstract : Parent-specific gene expression (genomic imprinting) is an evolutionary puzzle because it forgoes an important advantage of diploidy-protection against the effects of deleterious recessive mutations. Three hypotheses claim to have found a countervailing selective advantage of parent-specific expression. Imprinting is proposed to have evolved because it enhances evolvability in a changing environment, protects females against the ravages of invasive trophoblast, or because natural selection acts differently on genes of maternal and paternal origin in interactions among kin. The last hypothesis has received the most extensive theoretical development and seems the best supported by the properties of known imprinted genes. However, the hypothesis is yet to provide a compelling explanation for many examples of imprinting.
    Keywords : animals, evolution, molecular, female, gene expression, gene expression regulation, gene expression physiology, genomic imprinting, genomic imprinting genetics, humans, male, models, genetic, parents, selection, sex factors

    Subject : unspecified
    Area : Other
    Language : English
    Year : 2003

    Affiliations Ronin Institute, Montclair, NJ
    Journal : Nature Reviews Genetics
    Volume : 4
    Issue : 5
    Pages : 359-368
    Url : http://www.ncbi.nlm.nih.gov/pubmed/12728278

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