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    block this user Mahendra Kumar Trivedi

    Independent researcher

    Las Vegas Naveda
    Trivedi Global Inc.
    Trivedi Science Research Laboratory Pvt. Ltd

    Influence of Biofield Treatment on Physicochemical Properties of Hydroxyethyl Cellulose and Hydroxypropyl Cellulose

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    Cellulose based polymers have shown tremendous potential as drug delivery carrier for oral drug deliverysystem (DDS). Hydroxyethyl cellulose (HEC) and hydroxypropyl cellulose (HPC) are widely explored as excipientsto improve the solubility of poorly water soluble drugs and to improve self-life of dosage form. This work is anattempt to modulate the physicochemical properties of these cellulose derivatives using biofield treatment. Thetreated HEC and HPC polymer were characterized by X-ray diffraction (XRD), differential scanning calorimetry(DSC) and thermogravimetric analysis (TGA). The XRD studies revealed a semi-crystalline nature of both thepolymers. Crystallite size was computed using Scherrer’s formula, and treated HEC polymer showed a significantincrease in percentage crystallite size (835%) as compared to the control polymer. This higher increase in crystallitesize might be associated with greater crystallite indices causing a reduction in amorphous regions in the polymer.However treated HPC polymer showed decrease in crystallite size by -64.05% as compared to control HPC. DSCanalysis on HEC polymer revealed the presence of glass transition temperature in control and treated HEC polymer.We observed an increase in glass transition temperature in treated HEC, which might be associated with restrictedsegmental motion induced by biofield. Nonetheless, HPC has not showed any glass transition. And no change inmelting temperature peak was observed in treated HPC (T2) however melting temperature was decreased in T1 ascompared to control HPC. TGA analysis established the higher thermal stability of treated HEC and HPC. CHNSOresults showed significant increase in percentage oxygen and hydrogen in HEC and HPC polymers as compared tocontrol samples. This confirmed that biofield had induced changes in chemical nature and elemental composition ofthe treated polymers (HEC and HPC).

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    Description

    Title : Influence of Biofield Treatment on Physicochemical Properties of Hydroxyethyl Cellulose and Hydroxypropyl Cellulose
    Author(s) : Mahendra Kumar Trivedi
    Abstract : Cellulose based polymers have shown tremendous potential as drug delivery carrier for oral drug deliverysystem (DDS). Hydroxyethyl cellulose (HEC) and hydroxypropyl cellulose (HPC) are widely explored as excipientsto improve the solubility of poorly water soluble drugs and to improve self-life of dosage form. This work is anattempt to modulate the physicochemical properties of these cellulose derivatives using biofield treatment. Thetreated HEC and HPC polymer were characterized by X-ray diffraction (XRD), differential scanning calorimetry(DSC) and thermogravimetric analysis (TGA). The XRD studies revealed a semi-crystalline nature of both thepolymers. Crystallite size was computed using Scherrer’s formula, and treated HEC polymer showed a significantincrease in percentage crystallite size (835%) as compared to the control polymer. This higher increase in crystallitesize might be associated with greater crystallite indices causing a reduction in amorphous regions in the polymer.However treated HPC polymer showed decrease in crystallite size by -64.05% as compared to control HPC. DSCanalysis on HEC polymer revealed the presence of glass transition temperature in control and treated HEC polymer.We observed an increase in glass transition temperature in treated HEC, which might be associated with restrictedsegmental motion induced by biofield. Nonetheless, HPC has not showed any glass transition. And no change inmelting temperature peak was observed in treated HPC (T2) however melting temperature was decreased in T1 ascompared to control HPC. TGA analysis established the higher thermal stability of treated HEC and HPC. CHNSOresults showed significant increase in percentage oxygen and hydrogen in HEC and HPC polymers as compared tocontrol samples. This confirmed that biofield had induced changes in chemical nature and elemental composition ofthe treated polymers (HEC and HPC).
    Keywords : biofield,trivedi effect,the trivedi effect,mahendra trivedi, mahendra kumar trivedi

    Subject : pharmaceuticals
    Area : Open Access
    Language : English
    Year : 2015

    Affiliations Trivedi Global Inc.
    Trivedi Science Research Laboratory Pvt. Ltd
    Journal : Molecular Pharmaceutics & Organic Process Research
    Volume : 3
    Issue : 2
    Publisher : Omics
    Doi : 10.4172/2329-9053.1000126

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    Mahendra's Peer Evaluation activity

    Downloads 33145
    Views 199
    Following... 21
    • Alejandro Engelmann, Independent researcher, Library, Swedish University of Agricultural Sciences, Uppsala, Sweden.
    • Selma Dorrestein, Student, Master Level, University of Amsterdam.
    • Francisco Herrera, Publisher, UNIVERSITY OF GRANADA.
    • Ralf Steinmetz, Professor, university.
    • Gregory Dudek, Professor, McGill University, School of Computer Science, Montreal, Canada.
    • Umberto Straccia, Senior Research Fellow, ISTI - CNR.
    • Sorin Cotofana, Associate Professor, Deft University of Technology, Faculty of Electrical Engineeting, Mathematics, and Computer Science. Computer Engineering, Delft, The Netherlands.
    • Stefan Trausan-Matu, Professor, Computer Science Department, Politehnica University of Bucharest, Research Institute for Artificial Intelligence.
    • Jean Quisquater, Professor, UCL Crypto Group.
    • Markus Jakobsson, Principal Research Fellow, PayPal, FatSkunk, Indiana University.
    • Michael Elad, Professor, Technion - Israel institute of Technology.
    • Andrew Lumsdaine, Professor, Indiana University.
    • Mikael Nilsson, Student, Ph.D. Level, Royal Institute of Technology, Stockholm, Sweden.
    • Emilie Combet, Lecturer, MVLS, University of Glasgow, Glasgow, Centre for Population and Health Sciences, Life-course Nutrition and Health.
    • Werner Muller, Professor, Faculty of Life Science, University of Manchester, Manchester.
    • Syam Mohan, Senior Research Fellow, Pharmacology, University of Malaya, Malaysia.
    • Ramy K Aziz, Lecturer, Department of Microbiology and Immunology, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
    • Paweł K. Jędrzejko, Associate Professor, Department of American and Canadian Studies of the Institute of English Cultures and Literatures, University of Silesia in Katowice, Poland.
    • Nader Ale Ebrahim, Independent researcher, Research Support Unit, Centre of Research Services, Institute of Research Management and Monitoring (IPPP), University of Malaya, Malaysia.
    • Kelli Barr, Student, Ph.D. Level, Department of Philosophy and Religion Studies, University of North Texas, Denton, TX.
    • Pandelis Perakakis, Post Doctorate, Economics department, Universitet Jaume I, Castellon.

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